There are numerous thousands of genes available in the human genome with the minuscule twists of RNA & DNA. The combination will express the entire characteristics and traits to make them unique. Each gene is provided with an alphanumeric code & name, which is referred to as a Symbol. Scientists will utilize this code for coordinating the research. In the earlier stage, some human genes around 27 were renamed. Due to misreading the symbols, the dates are displayed by the Microsoft Excel program. Initially, it is not a problem as unexpected. Within the world of spreadsheets, Excel is a common program utilized by Scientists. They use to conduct clinical trials and even track their work process.
The default settings of these applications are specially designed with more routine work. You can input the alphanumeric symbol of a gene into the Microsoft Excel or spreadsheet. MARCH1, a short form of Membrane Associated Ring-CH Type Finger 1 is displayed as 1-Mar (Date) in Excel program. It is corrupting data, even dangerous, and extremely frustrating for the scientists to manually restore the data. Most of the peer-reviewed scientific work is surprisingly affected and widespread. As per the 2016 study, the genetic data are examined & shared with the published 3,600 papers. It is roughly found that around 20% of the data are affected due to Excel errors.
Studies found that Excel errors are affecting the Genetic Date (Fifth) in Papers
Dezso Modos, the system biologist working at the UK Quadram Institute informed that the program is really annoying. Her job involves analyzing the new sequenced genetic data and each time it shows an error message. This is the most important software utilized by scientists for processing numerical data. It is another widespread tool and needs some computation skills to work on it. Either, it does not have an easy fix to resolve the issue. The Auto-formatting feature can’t be turned off in the Excel program.
It is required to change the data type for each individual column. A scientist can easily fix or resolve their own data with computation. However, it will introduce some excel errors while accessing the spreadsheet by other users. HGNC (Hugo Gene Nomenclature Committee) is in-charge of standardizing the gene names in the scientific body form. New guidelines are posted by HGNC for gene naming that includes symbols, which affect data retrieval and handling.
Moving forward, the proteins & human genes are expressed in the name or form of one-eye within the auto-formatting feature. The symbols of SEPT1 are created as SEPTIN1 and MARCH1 will display as MARCHF1, etc. To avoid future confusion, HGNC had stored the record of old names and symbols. It is clear from Bruford that the naming genes art should be driven by consensus. Similar to the lexicographers charged for updating the list of available dictionaries. The committee is sensitive to fulfill the individual requirements that affect their work.
Offense should be avoided for Gene Names with One Language
Keep in mind that this is not always the same case. During the frontier or earlier days of genetics, the creative scientists will utilize the gene naming like a playground. Leading to the various notorious genes such as Indy, Sonic, or Sonic hedgehog. The function of the gene with a reference to double the fruit flies with the life span when mutated.
As of now, HGNC will take matters firmly and never exceed the current guidelines with ego or whimsy. How to minimize confusion is one of the most important practical concerns to focus on. For this reason, the committee informed that the gene symbols must be specific, brief, and also unique. It is not possible to utilize the superscript or subscript, which includes Arabic numerals and Latin letters.
Offensive words cannot spell out actual words or names but need to hold a unique language. Bruford informed that they are not unusual and taken lightly to decide on renaming the genes. During searches, false positives are avoided by renaming the nouns of various gene symbols. Earlier, the MARS was changed to MARS1, WARS as WARS1, and CARS as CARS1. To avoid insult, need to make other changes as well.
Bruford says that the clinician must explain about the mutation of a child to their parent in a specific gene. HECA will utilize the gene named “Drosophila – Headcase Homolog” which is the equivalent gene available in a fruit fly. However, it is changed as a “Cell Cycle Regulator HDC Homolog” for avoiding the potential offense. Bruford informed that this could be the first time in the history of guidelines to rewrite the counter problems. These issues are created by the Microsoft Excel software.
As of now, it offers extremely positive reactions and some say as joyous. Janna Hutz, the geneticist informed the new guidelines of HGNC are shared on Twitter to reach the community. Hutz tweeted herself as “HGNC (Human Gene Nomenclature Committee) thrilled us by this announcement”. Mudra Hedge working in the Massachusetts Broad Institute as a computational biologist finally responded to the announcement. A Twitter user also said that this is the greatest news to hear on this day.
Microsoft won the battle against Human Genetics
Regarding the decision, there are some disagreements as per the notes from Bruford. However, it is focused only on a particular single question. Why it should be easier for renaming the human genes apart from its regular working process? Actually, there is a fight between the genetics community and Microsoft for the scientists to get back down. For this requested comment, there is no proper response from Microsoft. The simple theory from Bruford states that it is not worth changing the trouble. She informed that the Excel software is limited to utilize the case for gene names.
It is an incentive for Microsoft for making the significant changes to the Excel features. Since this program is utilized by numerous users or massive communities across the globe. She never thinks that the situation is bitter though. Bruford informed that it is not required to wait for a fix from a hypothetical Excel update to resolve issues. The scientists themselves need to introduce a new long-term solution. It is a brief about the Microsoft Excel program and human genes are available as long as we live. However, it is advisable to provide a name that works for everyone.